邓兴旺 博士，资深研究员，所长
Xing Wang Deng, Ph.D., Investigator,
The Director of National Institute of Biological Sciences, Beijing.
电话（Tel）：010-80726688-8388
传真（Fax）：010-80726689
E-mail：dengxingwang@nibs.ac.cn 教育经历Education
1982年 北京大学生物系植物生理生化专业学士
1989年 加利福尼亚大学伯克利分校植物生理及分子生物学博士
工作经历Professional Experience
2003年任北京生命科学研究所所长
The Director of National Institute of Biological Sciences, Beijing
2003-present Named Daniel C. Eaton Professor of Plant Biology at Yale
2001-present Professor, Department of MCD Biology, Yale University
2000-present Director, the Peking-Yale joint center for Plant Molecular Genetics and Agribiotechnology
1998-2001 Associate Professor with tenure, Department of MCD Biology, Yale University
1995-1998 Associate Professor with term, Department of MCD Biology, Yale University
1992-1995 Assistant professor, Department of Biology, Yale University
1989-1991 Post-doctoral research---Molecular and genetic analysis of photomorphogenesis in Arabidopsis thaliana, and in vitro Dnase I footprinting analysis of nuclear protein-promoter interactions of Oat PhyA gene.

研究概述：Research Description
我们的研究兴趣主要在细胞外刺激引起的细胞信号传递过程及其对机体发育的调节。主要集中在两方面：光调控的拟南芥幼苗的发育过程以及其在哺乳动物中普遍保守的一种细胞信号传递途径。我们在研究光信号对拟南芥发育调节的信号通路时，找到了10个多效性COP/DET/FUS位点，确定它们介导了光对拟南芥幼苗发育过程的调节。其中，COP1是拟南芥光形态建成的关键的抑制因子，在暗中在细胞核内作为E3通过26S蛋白体降解促进光形态建成的转录因子，而在光下COP1活性被抑制且在核内的丰度降低；另外一个基因COP10编码一个类似E2的蛋白，并以多亚基蛋白复合体存在。其余的多数基因编码一个高度保守的多亚基蛋白COP9复合体（COP9 signalosome）的不同亚基，COP9复合体是一个新的E3连接酶的调节因子，可以促进NEDD8/RUB1从特定的E3连接酶上解离下来。COP9复合体是细胞对外界刺激或胁迫产生反应的新的调节成分。目前，我们正在采用分子遗传和基因组学的方法，进一步深入地研究我们发现的在所有多细胞有机体中都保守的细胞调节蛋白及复合体的功能。我们希望了解胞外信号调节这些蛋白及复合体的信号转导机制，以及在环境刺激发生反应时这些蛋白及复合体对基因组表达模式的调节。

发表文章： Publications
1. Wei, N., and Deng, X. W. (2003). The COP9 signalosome. Ann. Rev. Cell. Dev. Biol. 19. 261-286
2. Yusuke Saijo, James A. Sullivan, Haiyang Wang, Jianping Yang, Yunping Shen, Vicente Rubio, Ligeng Ma, Ute Hoecker, and Xing Wang Deng (2003). The COP1-SPA1 interaction defines a critical step in Phytochrome A-mediated regulation of HY5 activity. Genes & Dev. Nov 1;17(21): 2642-2647
3. Yuling Jiao, Hongjuan Yang, Ligeng Ma, Ning Sun, Haiyuan Yu, Tie Liu, Ying Gao, Hongya Gu, Zhangliang Chen, Masamitsu Wada, Mark Gerstein, Hongyu Zhao, Li-Jia Qu*, and Xing Wang Deng (2003). A genome wide analysis of blue light regulation of Arabidopsis transcription factor gene expression during seedling development. Plant Physiol. Dec; 133(4): 1480-1493
4. Lei, L., and Deng, X.W. (2003). The COP9 signalosome: an alternative lid for the 26S proteasome? Trend in Cell Biol. Oct; 13(10): 507-509
5. Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N (2003). Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol. Cell. Biol. 23(19), 6790-6797.
6. Sullivan, J. A. And Deng, X. W. (2003). From seed to seed: the role of photoreceptors in Arabidopsis development. Developmental Biology 260, 289-297.
7. Zhaohua Peng, Yunping Shen, Suhua Feng, Xiping Wang, Brahma Nanda Chitteti, Richard D. Vierstra, and Xing Wang Deng (2003). Evidence for a physical association of the COP9 signalosome, the proteasome, and specific SCF E3 ligases in vivo. Current Biology13, R504-5.
8. Ping Wu, Ligeng Ma, Xingliang Hou, Mingyi Wang, Yungrong Wu, Feiyan Liu, and Xing Wang Deng (2003). Phosphate Starvation Triggers Distinct Alterations of Genome Expression in Arabidopsis Roots and Leaves. Plant Physiology 132,1260-71.
9. Serino, G., and Deng, X. W. (2003). The COP9 signalosome: regulating plant development through the control of proteolysis. Ann. Rev. Plant. Mol. Biol. 54, 165-82.
10. Wang, H. Y., and Deng, X. W. (2003). Dissecting the Phytochrome A dependent signaling network in higher plants. Trends In Plant Sciences 8,172-178.
11. Xiping Wang, Suhua Feng, Naomi Nakayama, W. L. Crosby, Vivian Irish, Xing-Wang Deng, Ning Wei (2003). The COP9 Signalosome Interacts with SCFUFO and Participates in Arabidopsis Flower Development. Plant Cell 15, 1071-82.
12. Feng, S., Ma, L., Wang, X., Xie, D., Dinesh-Kumar, S. P., Wei, N., and Deng, X. W. (2003). The COP9 Signalosome Physically Interacts with SCFCOI1 and Modulates Jasmonate Responses. Plant Cell 15,1083-1094.
13. Serino, G., Su, H. W., Peng, Z. H., Tsuge, T., Wei, N., Gu, H. Y., and Deng, X. W. (2003). Characterization of the last subunit of Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell 15: 719-731.
14. Ma, L. G., Zhao, H. Y.,and Deng, X. W. (2003). Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development. Development 130, 969-981.
15. Chunling Yi , Haiyang Wang , Ning Wei and Xing Wang Deng (2002). An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biology, 3(1):30. (http://www.biomedcentral.com/1471-2121/3/30).
16. Wang H, Ma L.G, Habashi, J., Li J.M, Zhao H.Y, Deng X.W. (2002). Analysis of far-red light regulated genome expression profiles of phytochrome A pathway mutants in Arabidopsis. Plant J. 32: 723-733.
17. Ligeng Ma, Ying Gao, Lijia Qu, Zhangliang Chen, Jinming Li, Hongyu Zhao, and Xing Wang Deng (2002). Genomic evidence for COP1 as repressor of light regulated gene expression and development in Arabidopsis. Plant Cell 14, 2383-2398.
18. Claus Schwechheimer, Giovanna Serino, and Xing Wang Deng (2002). The COP9 signalosome and AXR1 are required for multiple E3 ubiquitin ligase-mediated processes in Arabidopsis thaliana. Plant Cell 14, 2553-2563.
19. Yadav V, Kundu S, Chattopadhyay D, Negi P, Wei N, Deng XW, Chattopadhyay S.(2002). Light regulated modulation of Z-box containing promoters by photoreceptors and downstream regulatory , COP1 and HY5, in Arabidopsis. Plant J. 31(6), 741-753.

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20. Rebecca C. Fry, Jessica Habashi, Haruko Okamoto and Xing-Wang Deng (2002). Characterization of a Dominant phyA Mutation Reveals a Distinction of Phytochrome A and Phytochrome B Signal Propagation . Plant Physiology 130, 457-465.
21. Yule Liu, Michael Schiff, Giovanna Serino, Xing-Wang Deng, and Savithramma P. Dinesh-Kumar (2002). Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to tobacco mosaic virus. Plant Cell 14:1483-1496..
22. Magnus Holm, Li-Geng Ma, Li-Jia Qu and Xing-Wang Deng (2002). Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. Gene&Dev. 16:1247-1259.
23. Christian S. Hardtke, Haruko Okamoto, Chatanika Stoop-Myer and Xing-Wang Deng (2002). Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). Plant J. 30, 385-394.
24. Claus Schwechheimer and Xing-Wang Deng (2002). FPLC Gel Filtration pp. 226-228, In Weigel, D., and Glazebrook, J. ed. “Arabidopsis-A Laboratory Manual”. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
25. Jessica Habashi and Xing-Wang Deng (2002). Nondenaturing Gel Electrophoresis of Proteins. pp. 228-233, In Weigel, D., and Glazebrook, J. ed “Arabidopsis-A Laboratory Manual”. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.

26. Giovanno Serino and Xing Wang Deng (2002). Protein Coimmunoprecipitation. pp. 233-237. In Weigel, D., and Glazebrook, J. ed “Arabidopsis-A Laboratory Manual”. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
27. Genki Suzuki, Yuki Yanagawa, Shing F. Kwok, Minami Matsui, and Xing-Wang Deng (2002). Arabidopsis COP10 is an ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Gene&Dev. 16, 554-559 .
28. Haiyang Wang and Xing Wang Deng (2002). Arabidopsis FHY3 defines a key phytochrome A signaling component directly interacting with its homologous partner FAR1. EMBO J. 21(6):1339-1349.
29. Haiyang Wang and Xing Wang Deng (2002). Phytochrome signaling. In The Arabidopsis Book, eds. C.R. Somerville and E.M. Meyerowitz, American Society of Plant Biologists, Rockville, MD, DOI 10.1199-tab.0074 (http://www.aspb.org/downloads/arabidopsis/deng.pdf)
30. Schwechheimer, C., and Deng, X. W. (2002). Studying protein-protein interactions with the yeast two-hybid system. Chapter 9 in “Molecular Plant Biology: A practical Approach”, volume II, pages 173-198.
31. Ligeng Ma, Jinming Li, Lijia Qu, Zhangliang Chen, Hongyu Zhao, and Xing Wang Deng (2001). Light control of Arabidopsis development entails co-ordinated regulation of genome expression and cellular pathways. Plant Cell 13, 2589-2607.
32. Zhaohua Peng, Giovanna Serino, and Xing-Wang Deng (2001). Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted development processes in Arabidopsis. Plant Cell 13, 2393-2407.
33. Zhaohua Peng, Giovanna Serino, and Xing-Wang Deng (2001). A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3. Development 128, 4277-4288.
34. Wang H, Ma L.G, Li J.M, Zhao H.Y, Deng X.W. (2001). Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. Science 294, 154-158. (epublication and news on16th August).
35. Haruko Okamoto, Lijia Qu, Xing Wang Deng (2001). EID1, aids the fine-tuning of phytochrome A signal transduction in Arabidopsis? Plant Cell 13:1983-1986.
36. Schwechheimer, C., and Deng, X. W. (2001). The COP9 signalosome revisited: A novel mediator of protein degradation. Trends Cell Biol. 11, 420-426.
37. Haruko Okamoto, Minami Matsui, Xing Wang Deng (2001) Overexpression of the heterotrimeric G-protein 　-subunit enhances phytochrome mediated inhibition of hypocotyl elongation in Arabidopsis. Plant Cell 13, 1639-1652.
38. Schwechheimer, C., G. Serino , Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R. J., Gray, W. M., Estelle, M., and Deng, X. W. (2001). The COP9 signalosome associates with SCFTIR1 ubiquitin ligase and plays a critical role for SCFTIR1-mediated auxin responses. SCIENCE, 292 (May 18), 1379-1382 (news focus on May 3 issue).
39. Zhaohua Peng, Jeffrey M. Staub, Giovanna Serino, Shing F. Kwok , Jasmina Kurepa, Barry D. Bruce, Richard D. Vierstra, Ning Wei, and Xing-Wang Deng (2001). The cellular level of PR500, a protein complex related to the 19S regulatory particle of the proteasome, is regulated in response to stresses in plants. Mol. Biol. Cell 12, 383-392.
40. Magnus Holm, Christian S. Hardtke, Rachelle Gaudet, and Xing-Wang Deng (2001). Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. EMBO J. 20: 118-127.
41. Yoshiharu Y. Yamamoto, Xing-Wang Deng, and Minami Matsui (2001). CIP4, a new COP1 target, is a nuclear-localized positive regulator of Arabidopsis photomorphogenesis. Plant Cell 13, 399-411.
42. Jiang CJ, Shoji K, Matsuki R, Baba A, Inagaki N, Ban H, Iwasaki T, Imamoto N, Yoneda Y, Deng XW, Yamamoto N (2001). Molecular cloning of a novel importin a homologue from rice, by which COP1 NLS-protein is preferentially nuclear imported. J Biol Chem. 276(12):9322-9329.
43. Abel S, Blazquez M, Dangl J, Deng XW, Graham I, Harada J, Jones J, Nilsson O. (2000). Arabidopsis Research 2000. Plant Cell. 12, 2302-2308.
44. CS. Hardtke, and XW Deng (2000). The cell biology of the COP/DET/FUS proteins: regulating proteolysis in photomorphogenesis and beyond? Plant Physiol. 124: 1548-1557.
45. Osterlund, M. T., Wei, N., and X.W. Deng (2000). The Roles of Photoreceptor Systems and the COP1-Targeted Destabilization of HY5 in Light Control of Arabidopsis Seedling Development. Plant Physiol. 124: 1520-1524.
46. Schwechheimer, C., and Deng, X. W. (2000). The COP/DET/FUS proteins---regulators of eukaryotic growth and development. Sem. Cell Dev. Biol. 11, 495-503.
47. CS. Hardtke, K. Gohda, MT. Osterlund, T. Oyama, K. Okada, and XW Deng (2000). HY5 stability and activity in Arabidopsis is regulated by phosphorylationin its COP1 binding domain. EMBO J. 19, 4997-5006.
48. O. Leyser and Deng, XW (2000). Cell signaling and gene regulation: new directions in plant signalling. Curr. Opin. Plant Biol. 3, 351-352.
49. Dingming Kang, Xiping Wang, Kaiming Cao, Chongrong Sun, Xing-Wang Deng, and Ning Wei. (2000). Functional conservation of COP9 signalosome among diverse organisms revealed by expressing heterologous subunit genes in Arabidopsis. Plant Journal, 23, 597-608.
50. Hsu-Liang Hsieh, Haruko Okamoto, Mingli Wang, Lay-Hong Ang, Minami Matsui, Horward Goodman, and Xing Wang Deng (2000). FIN219, an auxin-regulated gene, defines a link between phytochrome A and the downstream regulator COP1 in light control of Arabidopsis development. Genes Dev. 14: 1958-1970.
51. Deng, X.W., Dubiel, W., Wei, N., Hofmann, K., Mundt, K., Colicelli, J., Kato, J.Y., Naumann, M., Segal, D., Seeger, M., Glickman, M., Carr, A., and Chamovitz, D. A. (2000). Unified nomenclature for the COP9 signalosome: an essential regulator of development. Trends Genetics. 16, 202-203.
52. Osterlund, M. T., Hardtke, C., Wei, N., and X.W. Deng (2000). Targeted destabilization of HY5 during light regulated development of Arabidopsis. Nature 405, 462-466.
53. Yamamoto, Y. Y., Puente, P., and X. W. Deng (2000). Cotyledon-specific albino mutants of Arabidopsis defective in chloroplast gene expression and 16S rRNA maturation. Plant Cell and Physiology 41, 68-76.