裴钢研究员，中科院上海生命科学院生物化学与细胞生物学研究所研究员，中国科学院院士，中科院上海生命科学院院长。 1981年毕业于沈阳药科大学获学士学位、1984年获硕士学位。1985年在比利时Ghent国立大学UNIDO/WHO学习班进修药物学。 1986年在瑞典卡罗林斯卡研究所临床药理系进行访问研究。1991年获美国北卡大学生物化学和生物物理学博士学位，其后在美国杜克大学进行博士后研究。 1995年中科院上海细胞所在世界范围内公开招聘学术带头人，裴钢博士应聘担任中国科学院/德国Max Planck学会青年科学家小组组长和中国科学院上海细胞生物学研究所研究员，成立了细胞信号转导研究组，开展对G蛋白偶联受体信号转导的调控以及与其它信号转导体系间相互作用(cross-talk)的研究。近年来，其研究组对阿片类药物毒品成瘾的分子、细胞及神经机制进行了广泛系统地研究，取得了显著的成绩。
其现在的主要研究方向：
1、G蛋白偶联受体信号转导的反馈调控
2、细胞信号转导通路间的相互作用
3、阿片类药物耐受成瘾的分子、细胞和神经机制
4、中药作用的机理探讨
裴钢研究员领导的研究组近年来在国际学术刊物上发表学术论文70多篇，已被SCI收录的专业杂志引用数百次。该研究组和合作单位共同完成的蛋白激酶在阿片类物质介导神经信号的转导和赖受依赖中的作用》获2002年国家自然科学二等奖,“阿片类药物耐受和成瘾的分子机制研究”获2001年（首届）中华医学科技奖一等奖, “阿片受体磷酸化及其对受体信号转导的调控机制” 获2001年上海市科技进步一等奖；“孤啡肽受体及阿片受体的信号传导机理研究”获1998年度中华人民共和国教育部科学技术进步奖一等奖。与刘新垣院士的合作项目“白细胞介素2镇痛机制”获1997年上海市科技进步三等奖。
裴钢研究员于1996年获国家杰出青年科学基金，1997年获（香港）求是科技基金会“杰出青年学者奖”，1998年获得国务院颁发的政府特殊津贴,1999年获“何梁何利”生命科学奖并当选中国科学院院士，2001年当选上海市政协委员，2002年当选第三世界科学院院士。
其研究组几年来为国家培养了许多品学兼优、基本功扎实、勇于攀登世界高峰的年轻科学人材。数名博士后研究人员分别获得“中国优秀博士后”、等荣誉；研究生中亦有多人获得中科院院长奖学金优秀奖及各种冠名奖。其本人被评为中国科学院“优秀研究生导师”。 裴钢研究员现任中国细胞生物学会副理事长和国际麻醉品研究会议（INRC）执委会委员，并担任国际学术杂志“Life Science”，“Journal of Receptors and Signal Transduction”和国内多种学术刊物编委。
近年来发表的主要研究论文：
1. Ping Wang, Hua Gao, Yanxiang Ni, Beibei Wang, Yalan Wu, Lili Ji, Linhua Qin, Lan Ma, Gang Pei. β-Arrestin2 functions as a GPCR-activated regulator ofoncoprotein Mdm2. (2003) J. Biol. Chem. Accepted.
2. Lu Pu*, Guo-Bin Bao*, Nan-Jie Xu, Lan Ma, and Gang Pei Hippocampal Long-Term Potentiation Is Reduced by Chronic Opiate Treatment and Can Be Restored by Re-Exposure to Opiates. (2002) The Journal of Neruoscience. 22:1914-1921
3. Yue Sun, Zhijie Cheng, Lan Ma, and Gang Pei. Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis and this is mediated by its enhancement of p38 MAPK activation. (2002) J. Biol. Chem. 277：49212-9
4. Bo CEN, YING XIONG, LAN MA, and GANG PEI. Direct and Differential Interaction of b-Arrestins with the Intracellular Domains of Different Opioid Receptors. (2001) Mol. Pharmacol 59:758-764.
5. Nan-Jie Xu, Ling-Zhi Wang, Chun-Fu Wu, Gang Pei. Spatial learning and morphine-rewarded place preference negatively correlates in mice. (2001) Pharmacology Biochemistry and Behavior .68:389-394
6. Bo Cen, Qijngming Yu, Jun Guo, Yalan Wu, Kun Ling, Zhijie Cheng, Lan Ma and Gang Pei. Direct binding of b-Arrestins to two distinct intracellular domains of delta opioid receptor. (2001) J. Neurochemistry.76: 1887-1894
7. Tian-Hua Zhou, Kun Ling, Jun Guo, Hui Zhou, Ya-Lan Wu, Qing Jing , Lan Ma , and Gang Pei. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.(2000) J-Biol-Chem. 275(4): 2513-2519
8. Zhi-Jie Cheng, Jian Zhao, Yue Sun, Wei Hu, Ya-Lan Wu, Bo Cen, Guo-Xiang Wu, and Gang Pei. Beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. (2000) J-Biol-Chem. 275(4): 2479-2485
9. Ping Wang, Ya-Lan Wu, Tian-Hua Zhou, Yue Sun, and Gang Pei. Identification of alternative splicing variants of the b-subunit of human Ca2+/calmodulin-dependent protein kinase II with different activities. (2000) FEBS Letters 475:107-110.
10. Qing Jing, Shun-Mei Xin, Wen-Bo Zhang, Ping Wang, Yong-Wen Qin, and Gang Pei. Lysophosphatidycholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis. (2000) Circulation Research, 87:52-59.
11. LIGUANG LOU, TIAN HUA ZHOU, PING WANG, and GANG PEI. Modulation of calcium/calmodulin-dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: differential regulation of a and b isoforms (1999) Mol. Pharmacol. 55: 557-563.
12. Qing Jing, Sun-Mei Xin, Zhi-Jie Cheng, Wen- Bo Zhang, Ru Zhang, Yong-Wen Qin, and Gang Pei. Activation of p38 MAPK by oxidized LDL in vascular smooth muscle cells: mediation via pertussis toxin-sensitive G proteins and association with oxidized LDL-induced cytotoxicity (1999) Circulation Research. 84:831-839.
13. KUN LING, PING WANG, JIAN ZHAO, YA-LAN WU, ZHI-JIE CHENG, GUO-XIANG WU, WEI HU, LAN MA, AND GANG PEI. Five-transmembrane domains appear sufficient for a G protein-coupled receptor; Functional five-transmembrane domain chemokine receptors. (1999) Proc. Natl. Acad. Sci. 96: 7922-7927.
14. Jian Zhao, Li-Hong Ben, Ya-Lan Wu, Wei Hu, Kun Ling, Shun- Mei Xin, Hui-ling Nie, Lan Ma, and Gang Pei. Anti-HIV Agent Trichosanthin Enhances the Capabilities of Chemokines to Stimulate Chemotaxis and G Protein Activation, and This Is Mediated through Interaction of Trichosanthin and Chemokine Receptors. (1999) J. Exp. Med. 190:101-111.
15. GUO-HUANG FAN, LING-ZHI WANG, HAO-CHUN QIU, LAN MA, and GANG PEI. Inhibition of Calcium/Calmodulin-Dependent Protein Kinase II in Rat Hippocampus Attenuates Morphine Tolerance and Depecdence. (1999) Mulecular Pharmacology, 56: 39-45.
16. ZheZhang, Shun-Mei Xin, Guo-Xiang Wu, Wen-Bo Zhang, Lan Ma, and Gang Pei. Endogenous d-Opioid and ORL1 Receptor Couple to Phosphorylation and Activation of p38 MAPK in NG108-15 Cells and This Is Regulated by protein Kinase A and Protein Kinase C. (1999) J. Neurochemistry.73: 1502-1509.
17. Qing-Ming Yu, Zhi-Jie Cheng, Xiao-Qing Gan, Guo-Bin Bao,Lin Li, and Gang Pei. The Amino Terminus with a Conserved Glutamic Acid of G Protein-Coupled Receptor Kinase Is Indispensable for Their Ability to Phosphorylate Photoactivated Rhodopsin. (1999) J. Neurochemistry, 73: 1222-1227
18. Lu Pu, Guo-Bin Bao, Lan Ma, and Gang Pei. Acute desensitization of nociceptin/orphanin FQ inhibition of voltage-gated calcium channels in freshly dissociated hippocampal neurons. (1999) European Journal of Neuroscience. 11: 3610-3616
19. Li-Guang Lou, Zhe Zhang, Lan Ma, and Gang Pei. Nociceptin/Orphanin FQ activates mitogen-activated protein kinase in Chinese Hamster ovary cells expressing opioid receptor-like receptor. (1998) J. Neurochem. 70: 1316-1322.
20. GUO-HUANG FAN, JING ZHAO, YA-LAN WU, ZHE ZHANG, LI-GUANG LOU, QING JING, LAN MA, and GANG PEI. N-methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C. (1998) Mol. Pharmacol. 53: 684-690.
21. Zhi-Jie Cheng, Qing-Ming Yu, Ya-Lan Wu, Lan Ma, and Gang Pei. Selective Interference of beta-Arrestin 1 with kappa and delta but not mu Opioid Receptor/G Protein Coupling. (1998) J. Biol. Chem. 273: 24328-24333.
22. YING-CHUN CAI, LAN MA, GUO-HUANG FAN, JING ZHAO, LI-ZHEN JIANG and GANG PEI. Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta opioid receptor. (1997) Mol. Pharmacol. 51: 583-587.
23. Gang Pei, Kun Ling, Lu Pu, Martin D. C Cunningham, Lan Ma. Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response involves protein kinase C. (1997) FEBS Lett. 412: 253-256.
E-MAIL：peilab@sibs.ac.cn
