参 考 文 献
1 Elbashir S M , Harborth J , Lendeckel W, et al . Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature , 2001 , 411 (6836) : 494～498
2 Carmichael G G. Medicine : silencing viruses with RNA. Nature ,2002 , 418 (6896) : 379～380
3 McManus M T , Sharp P A. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet , 2002 , 3 (10) : 737～747
4 Hannon GJ . RNA interference. Nature , 2002 , 418 (6894) : 244～251
5 Elbashir S M , Harborth J , Weber K, et al . Analysis of gene function in somatic mammalian cells using small interfering RNAs.Methods , 2002 , 26 (2) : 199～213
6 Harborth J , Elbashir S M , Bechert K, et al . Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci , 2001 , 114 (24) : 4557～4565
7 Krichevsky A M , Kosik K S. RNAi functions in cultured mammalian neurons. Proc Natl Acad Sci USA , 2002 , 99 (18) : 11926～11929
8 Tuschl T. Expanding small RNA interference. Nat Biotechnol , 2002 , 20 (5) : 446～468
9 Paddison P J , Caudy A A , Bernstein E , et al . Short hairpin RNAs (shRNAs) induce sequence2specific silencing in mammalian cells. Genes Dev , 2002 , 16 (8) : 948～958
10 McCaffrey A P , Meuse L , Pham T T , et al . RNA interference in adult mice. Nature , 2002 , 418 (6893) : 38～39
11 Brummelkamp T R , Bernards R , Agami R A , et al . System for stable expression of short interfering RNAs in mammalian cells. Science , 2002 , 296 (5567) : 550～553
12 Martinez M A , Clotet B , Este J A. RNA interference of HIV replication. Trends Immunol , 2002 , 23 (12) : 559～561
13 Jacque J M , Triques K, Stevenson M. Modulation of HIV21 replication by RNA interference. Nature , 2002 , 418 (6896) : 435～438
14 Lee N S , Dohhjima T , Bauer G, et al . Expression of small interfering RNAs targeted against HIV21 rev transcripts in human cells. Nat Biotechnol , 2002 , 20 (19) : 500～505
15 Novina C D , Murray M F , Dykxhoorn D M , et al . siRNA-directed inhibition of HIV21 infection. Nat Med , 2002 , 8 ( 7) :681～686
16 Kitabwalla M , Ruprecht RM. RNA interference——a new weapon against HIV and beyond. N Engl J Med , 2002 , 347 (17) : 1364～1367
17 Borkhardt A. Blocking oncogenes in malignant cells by RNA interference——new hope for a highly specific cancer treatment ? Cancer Cell , 2002 , 2 (3) : 167～168
18 Brummelkamp T R , Bernards R , Agami R. Stable suppression of tumorigenicity by virus2mediated RNA interference. Cancer Cell ,2002 , 2 (3) : 243～247
19 Scherr M , Battmer K, Winkler T , et al . Specific inhibition of bcrabl gene expression by small interfering RNA. Blood , 2003 , 101(4) : 1566～1569
20 Wilda M , Fuchs U , Wossmann W, et al . Killing of leukemic cellswith a BCR/ ABL fusion gene by RNA interference ( RNAi ) .Oncogene , 2002 , 21 (37) : 5716～5724
