Introduction
Parameters for the Design of Effective Short Hairpin RNAs . . . . .. . . . . . . . . 1
Bryan R. Cullen, PhD
Lentiviral Strategies for RNAi Knockdown of Mammalian Genes . . . .. . 5
Michael T. McManus, PhD
MicroRNA Expression Patterns in the Brain . . . . . . . . . 13
Kenneth S. Kosik, MD, and Anna M. Krichevsky, PhD
Determining the Roles of Small Noncoding RNAs in Adult Neural Stem Cells . . . 19
Jenny Hsieh, PhD, Tomoko Kuwabara, PhD, and Fred H. Gage, PhD
RNAi in Neurodegenerative Disease: Viral Vectors and Applications . . . . . 25
Beverly L. Davidson, PhD
RNAi for Disease: Allele-Specific Silencing . . . . . . .. . . . . . . 33
Henry L. Paulson, MD, PhD
