摘要：在炎症反应中，白细胞在血液流动动力和粘附分子的作用下在血管内皮上的滚动，是白细胞从流动的血液中浸润、迁
移到炎症部位整个过程的第一步。白细胞在内皮细胞上滚动由选择素分子与其配体分子相互作用所导致，其中P选择素分子(P
— sclectin)与其对应的P一选择素糖蛋白配体一l(PSGL—1)的相互作用起着重要的作用。原子力显微镜技术能定量分析P—se．
1ectin／PSGL—l相互作用的动力学反应。
关键词：P选择素；P一选择素糖蛋白配体一l；原子力显微镜

M easuring M olecule Adhesion Forces In Inflannnatory Processes
with Atomic Force Microscope(AFM)
YEZhi—yi，qUANXue一 m
Chonqing institute oftechnology，Chongqing 400O50，China cIl峨 ，Chongqi~ 400O44，Ch／na
ABSTRACr：Leukoeytes roll alongthe endothelium ofpostcapill=y venuhein responsetOinflanmaatory andthrombotic processes，which
is，under hydrodynamic shear forces，the first step in directing leukoeytes out ofthe blood stre．8ln into sites 0finflammation。and mainly resulted from the interaction between P—seleetin on the endothelia]cell membrane and P—seletin glyeoprotein ligand一1(PSGL一1)on the leucocyte microvilli．Kinetics ofP—seleetin／FSGL-1 interaction was made a quantitative analysis by llsing atomic force microscope(AFM)．
Key words：P—seletin；PSGL—I；Atomic force microscopy(AFM)