Symposiumon Stemcells: nuclear reprogramming and therapeutic applications, held attheNovartis
Foundation,London, 2^4March 2004.
Editors:Gregory Bock (Organizer) and JamieGoode
This symposiumis based onproposalsmade byKarin BlumerandUwe Junker, andAdamWilkins
John Gearhart Chair’s introduction 1
Davor Solter What is a stem cell? 3
Discussion 12
Markus Grompe Bone marrow-derived hepatocytes 20
Discussion 28
Irving L.Weissman Normal and neoplastic stem cells 35
Discussion 50
CatherineM.Verfaillie Multipotent adult progenitor cells: an update 55
Discussion 61
Steven A. Goldman and Fraser Sim Neural progenitor cells of the adult brain 66
Discussion 82
General discussion I Stem cells in the brain 92
Martin Evans Embryonic stem cells: a perspective 98
Discussion 103
Rudolf Jaenisch, KonradHochedlinger and Kevin Eggan Nuclear cloning,
epigenetic reprogramming and cellular di¡erentiation 107
Discussion 118
General discussion II 122
J. B. Gurdon, J. A. Byrne and S. Simonsson Nuclear reprogramming by
Xenopus oocytes 129
Discussion 136
BernardoNadal-Ginard, Piero Anversa, Jan Kajstura and Annarosa Leri
Cardiac stem cells and myocardial regeneration 142
Discussion 154
Bernat Soria, Enrique Roche, Juan A. Reig and FranzMartin Generation of
insulin-producing cells from stem cells 158
Discussion 167
Anders Bj˛rklund Cell therapy for Parkinson’s disease: problems and
prospects 174
Discussion 187
ThomasH.Murray Ethical (and political) issues in research with human stem
cells 188
Discussion 196
Final discussion The regulatory environment 204
Index of contributors 212
Subject index 214
