Tetsuya Nosaka
Introduction 1
Modes of Jak Activation in Cytokine Signaling . 1
Jak Function Determined by Targeted Gene Disruption .. 3
Conclusions . 6
2. Jak3-Dependent Pathways in Hematopoiesis and SCID . 10
Nicholas A. Cacalano and James A. Johnston
Introduction . 10
Jak3-Regulated Signal Transduction Pathways 11
Models of Jak3 Deficiency . 19
Jak3 in Positive and Negative Selection of Thymocytes .. 25
Role of Jak3 in Innate Immunity 26
Role of Jak3 in the Periphery 28
Knockouts of Jak3-Dependent Signaling Components 30
Conclusions .. 41
3. Stat Activation by Src, Fes and Btk Tyrosine Kinases 51
Thomas E. Smithgall
Introduction . 51
Src Kinases 52
The c-Fes Tyrosine Kinase. 62
The Btk Kinase Family 68
Conclusions .. 71
4. Stats and Hematopoiesis . 78
Alister C. Ward
Introduction . 78
Stat Proteins . 78
Role of Stats in Hematopoietic Processes 81
Mechanisms of Stat Action 84
Unanswered Questions 85
Conclusions .. 86
Acknowledgements 86
5. Stat Signaling in Leukemia: Implications
for Pathogenesis and Treatment .. 92
David A. Frank
Introduction . 92
Human Leukemia . 93
Stat Activation in Leukemias 93
Targeting Stats in Anti-Leukemia Therapy . 101
Conclusion . 106
6. The Role of the Jak-Stat Pathway in Hematopoiesis
and Immune Responses in Drosophila .. 112
Erika A. Bach and Norbert Perrimon
Introduction .. 112
The Jak-Stat Pathway 113
The Drosophila Jak-Stat Pathway 114
Hematopoiesis in Drosophila 116
Signaling Pathways Involved in Larval Hematopoiesis .. 120
Immune Responses in Drosophila .. 121
Conclusions 122
7. SOCS Proteins in Hematopoiesis . 127
Sandra Nicholson and Warren Alexander
Introduction .. 127
SOCS Proteins . 128
Mechanisms of Action of SOCS Proteins 129
Physiological Roles of the SOCS Proteins 132
Conclusions 135
Index .. 139
