最近rosetta@home的用户正在检测预测CASP7结构的实验,将在8月4日结束。
CASP7完成设计后,David Baker等人将把用户的计算能力引导到重要的设计问题中,例如开发HIV的疫苗。人类难以对付HIV的主要原因是HIV上的病毒衣壳蛋白(viral coat protein)—gp120,具有许多高度可变环。针对HIV的免疫反应倾向于瞄准这些可变区域,因此相对来说不能起到有效的反应。然而,gp120上具有一些关键的区域是不可变的,因为它们是HIV侵染所必需的。研究小组中的Bill Schief与NIH(National Institutes of Health)D的Peter Kwong等人的研究小组合作,设计了一系列的新型蛋白疫苗来模仿这些HIV的不可变区域。
这些例子仅仅是开始。蛋白设计的潜力就好像生物学自身的多样性一样。具有创造未有的催化剂,改进生物分子的相互作用,和设计新的有用蛋白的能力后,剩下的事就仅受想象力和计算能力所限制了。(以上内容来自华盛顿大学HHMI研究员David Baker)(生物通:亚历)
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